Israel is facing growing international warnings over its planned offensive in Rafah – the city in southern Gaza crammed with Palestinian refugees.
UK Foreign Secretary David Cameron said “over half of Gaza’s population are sheltering in the area”, while Dutch FM Hanke Bruins Slot said there could be “many civilian casualties”.
Saudi Arabia warned of “very serious repercussions” if Rafah was stormed.
Gaza’s Hamas rulers said there could “tens of thousands” of casualties.
Israel launched its operations in the Palestinian enclave after more than 1,200 people were killed in southern Israel on 7 October by Hamas gunmen.
More than 27,900 people have been killed and at least 67,000 injured in Gaza since then, according to the Hamas-run health ministry.
Many Gazans have ended up in Rafah having been forced to flee their homes elsewhere at least once.
Saturday’s warnings came a day after Israeli Prime Minister Benjamin Netanyahu ordered his military to prepare to evacuate civilians from the city ahead of an expanded offensive against Hamas.
“It is impossible to achieve the goal of the war without eliminating Hamas, and by leaving four Hamas battalions in Rafah. It is clear that intense activity in Rafah requires that civilians evacuate the areas of combat,” Mr Netanyahu’s office said.
The prime minister also rejected Hamas’s latest proposed ceasefire terms.
The US has already warned Israel that an invasion of Rafah as part of its assault on Gaza would be a “disaster”, while the EU and the UN both expressed their own concerns.
Aid groups say it is not possible to evacuate everyone from the city on the border with Egypt.
Some 1.5 million Palestinians are believed to be in Rafah, seeking refuge from Israeli combat operations in the rest of the Gaza Strip. Most of them are living in tents.
In a social media post, Mr Cameron said he was “deeply concerned about the prospect of a military offensive in Rafah.
“The priority must be an immediate pause in the fighting to get aid in and hostages out, then progress towards a sustainable, permanent ceasefire.”
Meanwhile, Ms Bruins Slot described the situation in Rafah as “very worrying”.
“Many civilians in Gaza have fled south. Hard to see how large-scale military operations in such a densely populated area would not lead to many civilian casualties and a bigger humanitarian catastrophe. This is unjustifiable,” she added.
Also on Saturday, the Saudi foreign ministry issued a statement that warned against “targeting the city of Rafah in the Gaza Strip, which is the last resort for hundreds of thousands of civilians forced by the brutal Israeli aggression to flee”.
The ministry also repeated its “demand for an immediate ceasefire”.
In other developments on Saturday:
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At least five Palestinians were killed in Israeli airstrikes on Rafah, according to the Palestinian news agency, Wafa
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The Israel Defense Forces (IDF) said its air force killed two Hamas operatives in the southern city
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The IDF also said it discovered a tunnel shaft near a school run by the relief agency for Palestinian refugees (UNRWA) that was leading to an “underground terrorist tunnel beneath UNRWA’s main headquarters”
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UNRWA head Philippe Lazzarini denied any knowledge of a Hamas tunnel near the agency’s office – a building which he said his staff vacated months ago
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A six-year-old girl who went missing in Gaza City last month was found dead with several of her relatives and two paramedics – after appearing to come under fire from Israeli tanks
The BBC is unable to independently verify many battlefield claims made during the course of the war.