Index Investing News
Saturday, May 24, 2025
No Result
View All Result
  • Login
  • Home
  • World
  • Investing
  • Financial
  • Economy
  • Markets
  • Stocks
  • Crypto
  • Property
  • Sport
  • Entertainment
  • Opinion
  • Home
  • World
  • Investing
  • Financial
  • Economy
  • Markets
  • Stocks
  • Crypto
  • Property
  • Sport
  • Entertainment
  • Opinion
No Result
View All Result
Index Investing News
No Result
View All Result

Antibody-drug conjugates key to Pfizer’s Seagen acquisition

by Index Investing News
April 2, 2023
in Markets
Reading Time: 2 mins read
A A
0
Home Markets
Share on FacebookShare on Twitter


Love Employee

Pfizer’s (NYSE:PFE) acquisition of Seagen (NASDAQ:SGEN), announced in March, is expected to complement the pharma giant’s current portfolio of oncology therapies.

Seagen focuses on antibody-drug conjugates (ADCs), a technology that the company says can “harness the targeting power of antibodies to deliver small molecule drugs to the tumor.”

The biotech has three marketed ADCs: Adcetris (brentuximab vedotin), Padcev (enfortumab vedotin), and Tivdak (tisotumab vedotin). They are approved for various types of cancer.

In addition, it markets a non-ADC, Tukysa (tucatinib), which is approved for breast and colorectal cancers.

On March 13, Pfizer (PFE) said it would acquire Seagen for $43B. Should the deal go through, it would be the biggest in the pharma sector since AbbVie (ABBV) paid $63B in 2019 for Allergan.

Despite the steep price tag for Pfizer (PFE), the payoff down the line is expected to be huge. In a recent report, data and analytics company GlobalData said Pfizer’s (PFE) total cumulative revenue from Seagen’s (SGEN) products is projected to hit $36B by 2028.

The acquisition comes at a critical time for Pfizer (PFE) as it is facing declining revenues of its COVID-19 vaccine and antiviral Paxlovid, two products which significantly padded its top line in recent years.

In its Q4 and full-year 2022 earnings report released in January, Pfizer (PFE) said that Paxlovid generated ~$19B in sales for the year. However, it warned that in 2023, that figure would decline 58% to $8B.

The good news for Pfizer (PFE) is that GlobalData sees the Seagen (SGEN) acquisition as a good fit. “What’s most impressive…is Seagen’s (SGEN) ability to develop a wide range of monoclonal antibodies, that target different cancer types,” says GlobalData Oncology & Hematology Analyst Israel Stern. “This capacity will now be enhanced by leveraging Pfizer’s (PFE) protein engineering capabilities.”

Stern noted that all four of Seagen’s (SGEN) currently marketed therapies are expected to have $1B in revenue in the next five years. Adcetris, the biotech’s top-selling drug, is approved for several lymphoma types. GlobalData projects it will become a billion-dollar drug in 2024.

Padcev, which was developed with Astellas Pharma (OTCPK:ALPMF)(OTCPK:ALPMY) urothelial cancer, is projected to overtake Adcetris as its top-selling drug by 2024, Stern added.

Padcev could see additional use as it is currently under Priority Review by the US FDA in combination with Keytruda (pembrolizumab) for urothelial cancer.

Seagen’s (SGEN) pipeline is also promising. Besides pursuing additional indications for its marketed products, it has two ADCs in phase 2, disitamab vedotin and ladiratuzumab vedotin. The former is under investigation for HER2 expressing urothelial cancer, while the latter for triple-negative breast cancer and solid tumors.



Source link

Tags: AcquisitionAntibodydrugconjugateskeyPfizersSeagen
ShareTweetShareShare
Previous Post

Ukraine asks court to put Orthodox leader under house arrest

Next Post

Binance, CZ And 3 Crypto Influencers Slapped With $1 Bn Lawsuit

Related Posts

ValueAct takes a stake in Rocket Cos. How the activist might assist raise shares

ValueAct takes a stake in Rocket Cos. How the activist might assist raise shares

by Index Investing News
May 24, 2025
0

FILE PHOTO: A banner celebrating Rocket Firms Inc., the mother or father firm of U.S. mortgage lender Quicken Loans, IPO...

Costco (COST) all set to report Q3 2025 earnings. Right here’s what to anticipate

Costco (COST) all set to report Q3 2025 earnings. Right here’s what to anticipate

by Index Investing News
May 23, 2025
0

Costco Wholesale Company (NASDAQ: COST) has delivered a formidable efficiency within the first half of FY25, aided by robust membership...

Goal Company (TGT): A take a look at how the retailer is navigating a troublesome atmosphere

Goal Company (TGT): A take a look at how the retailer is navigating a troublesome atmosphere

by Index Investing News
May 24, 2025
0

Shares of Goal Company (NYSE: TGT) stayed pink on Friday. The inventory has dropped 23% over the previous three months....

The Massive Lovely Bitcoin Breakout

The Massive Lovely Bitcoin Breakout

by Index Investing News
May 23, 2025
0

Bitcoin (BTC) broke $111,000 yesterday, an all-time excessive. Supply: coingecko.com And since everybody is aware of I’m a crypto bull,...

Goolsbee says Fed has to attend longer earlier than transferring charges as a result of commerce coverage uncertainty

Goolsbee says Fed has to attend longer earlier than transferring charges as a result of commerce coverage uncertainty

by Index Investing News
May 24, 2025
0

Chicago Federal Reserve President Austan Goolsbee stated Friday that President Donald Trump's newest tariff threats have difficult coverage and certain...

Next Post
Binance, CZ And 3 Crypto Influencers Slapped With  Bn Lawsuit

Binance, CZ And 3 Crypto Influencers Slapped With $1 Bn Lawsuit

Horror moment hot air balloon bursts into flames in mid air as two leap to their deaths and child hurt in Mexico

Horror moment hot air balloon bursts into flames in mid air as two leap to their deaths and child hurt in Mexico

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

RECOMMENDED

July Services PMI rises most rise since June 2010 on robust global demand

July Services PMI rises most rise since June 2010 on robust global demand

August 3, 2023
Trump order threatens wind initiatives that might energy tens of millions of houses

Trump order threatens wind initiatives that might energy tens of millions of houses

February 17, 2025
To search out the true Kamala Harris, look to her final marketing campaign

To search out the true Kamala Harris, look to her final marketing campaign

August 24, 2024
Russian Assault in Kramatorsk Kills 2 civilians, Regional Navy Chief Says

Russian Assault in Kramatorsk Kills 2 civilians, Regional Navy Chief Says

August 13, 2022
Which One Is Finest For Investing?

Which One Is Finest For Investing?

June 17, 2022
Reporters admit Politico snuffed out Hunter Biden laptop computer story to guard Joe in 2020

Reporters admit Politico snuffed out Hunter Biden laptop computer story to guard Joe in 2020

January 24, 2025

Metaverse Company Appoints Robot As Female CEO – Hasta La Vista Baby!

August 29, 2022
Lean FI in 6 Years, Fat FI in 10, and Quitting Your Job The FIRE Way

Lean FI in 6 Years, Fat FI in 10, and Quitting Your Job The FIRE Way

December 22, 2023
Index Investing News

Get the latest news and follow the coverage of Investing, World News, Stocks, Market Analysis, Business & Financial News, and more from the top trusted sources.

  • 1717575246.7
  • Browse the latest news about investing and more
  • Contact us
  • Cookie Privacy Policy
  • Disclaimer
  • DMCA
  • Privacy Policy
  • Terms and Conditions
  • xtw18387b488

Copyright © 2022 - Index Investing News.
Index Investing News is not responsible for the content of external sites.

No Result
View All Result
  • Home
  • World
  • Investing
  • Financial
  • Economy
  • Markets
  • Stocks
  • Crypto
  • Property
  • Sport
  • Entertainment
  • Opinion

Copyright © 2022 - Index Investing News.
Index Investing News is not responsible for the content of external sites.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In